ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

Base Information

Chemical Name:ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate
CAS No.:1272655-91-0
Molecular Formula:C₁₈H₃₅NO₃Si
Molecular Weight:341.566
Hs Code.:

Synonyms:ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

Suppliers and Price of ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

There total 1 articles about ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1272655-91-0
ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

Guidance literature:

Reference yield: 39.0%

: 1272655-91-0
ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 1272655-94-3
3-ethyl 2-(phenylmethyl) 8-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-azaspiro[4.5]decane-2,3-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.08333h;

Reference yield:

: 1272655-91-0
ethyl 8-((tert-butyldimethylsilyl)oxy)-2-azaspiro[4.5]decane-3-carboxylate

: 1272655-83-0
methyl [(1S)-1-({(2S)-2-[4-(4′-{2-[8,8-difluoro-2-((2S)-3-methyl-2-{[(methyloxy)carbonyl]amino}butanoyl)-2-azaspiro[4.5]-dec-3-yl]-1H-imidazol-4-yl}-4-biphenylyl)-1H-imidazol-2-yl]-1-pyrrolidinyl}carbonyl)-2-methylpropyl]carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: acetic acid; tetrabutyl ammonium fluoride / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3.1: Dess-Martin periodane / dichloromethane / 18 h / 20 °C / Inert atmosphere

4.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; ethanol / 2.5 h / 20 °C / Inert atmosphere

4.2: 18 h / Inert atmosphere

4.3: Resolution of racemate

5.1: hydrogen; 20% palladium hydroxide-activated charcoal / ethanol / 18 h / 3102.97 Torr / Inert atmosphere

6.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide / water; tetrahydrofuran; methanol / 0.5 h / 20 °C

8.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

9.1: ammonium acetate / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

With 20% palladium hydroxide-activated charcoal; ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4013104