6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene

Base Information

• Chemical Name: 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene
• CAS No.: 116409-24-6
• Molecular Formula: C₂₁H₂₂O₆
• Molecular Weight: 370.402
• NSC Number: 381583
• DSSTox Substance ID: DTXSID20922058
• Mol file: 116409-24-6.mol

Synonyms:116409-24-6;6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene;8H-1,3-Dioxolo(4,5-g)(1)benzopyran, 6,7-dimethyl-8-(3,4,5-trimethoxyph enyl)-;NSC381583;DTXSID20922058;NSC-381583;6,7-Dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo(4,5-g)(1)benzopyran;8H-1,3-Dioxolo(4,5-g)(1)benzopyran, 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-;6,7-Dimethyl-8-(3,4,5-trimethoxyphenyl)-2H,8H-[1,3]dioxolo[4,5-g][1]benzopyran

Chemical Property of 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene

Chemical Property:

• Vapor Pressure: 4.3E-08mmHg at 25°C
• Boiling Point: 456.7°Cat760mmHg
• Flash Point: 183.5°C
• PSA: 55.38000
• Density: 1.218g/cm³
• LogP: 4.25930
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 370.14163842
• Heavy Atom Count: 27
• Complexity: 549

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(OC2=CC3=C(C=C2C1C4=CC(=C(C(=C4)OC)OC)OC)OCO3)C

Technology Process of 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene

There total 5 articles about 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-[1,3]dioxolo[4,5-g]chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Sesamol (533-31-3) → 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo<4,5-g><1>benzopyran (116409-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / methanol / 0.5 h / Heating

2: 68 percent / methanol / 0.5 h / 100 °C

3: 98 percent / glacial acetic acid / H₂O / 1 h / 100 °C

4: 1.0 g / KHSO₄ (s) / 0.08 h / warmed to melting

With potassium hydrogensulfate; acetic acid; In methanol; water;

DOI:10.1002/jhet.5570250113

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo<4,5-g><1>benzopyran (116409-24-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / methanol / 0.5 h / Heating

2: 68 percent / methanol / 0.5 h / 100 °C

3: 98 percent / glacial acetic acid / H₂O / 1 h / 100 °C

4: 1.0 g / KHSO₄ (s) / 0.08 h / warmed to melting

With potassium hydrogensulfate; acetic acid; In methanol; water;

DOI:10.1002/jhet.5570250113

Reference yield:

1-<7,8-dihydro-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo<4,5-g><1>benzopyran-6-yl>pyrrolidine (116409-20-2) → 6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-8H-1,3-dioxolo<4,5-g><1>benzopyran (116409-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / glacial acetic acid / H₂O / 1 h / 100 °C

2: 1.0 g / KHSO₄ (s) / 0.08 h / warmed to melting

With potassium hydrogensulfate; acetic acid; In water;

DOI:10.1002/jhet.5570250113

upstream raw materials:

7,8-dihydro-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo<4,5-g><1>benzopyran-6-ol

Sesamol

3,4,5-trimethoxy-benzaldehyde

1-<7,8-dihydro-6,7-dimethyl-8-(3,4,5-trimethoxyphenyl)-6H-1,3-dioxolo<4,5-g><1>benzopyran-6-yl>pyrrolidine