[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester
CAS No.:713497-10-0
Molecular Formula:C₃₇H₅₇N₇O₁₀
Molecular Weight:759.9
Hs Code.:

[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Synonyms:[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Suppliers and Price of [(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

There total 14 articles about [(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52716-49-1
N-((3S)-1-bromo-2-oxo-5-methyl-3-hexyl)-t-butoxycarboxamide

: 713497-10-0
[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

1.2: 70 percent / tetrahydrofuran / 1.5 h

2.1: NaBH₄ / methanol; 2-methoxy-ethanol / 0.33 h

2.2: 51 percent / DMAP / CH₂Cl₂ / 24 h

3.1: 89 percent / Sn(OAc)2; (i-Pr)2NEt / dimethylformamide / 17 h / 80 °C

4.1: H₂; AcOH / PtO₂ / 5 h / 20 °C

5.1: 59 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 3 h

6.1: 96 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide / 48 h

7.1: 82 percent / AcOH / H₂O / 96 h / 25 °C

8.1: 79 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂; dimethylformamide / 3 h

9.1: HCl / dioxane; H₂O / 2 h

10.1: HATU; (i-Pr)2NEt / dimethylformamide / 20 h

11.1: Et₂NH / Pd(PPh₃)4 / tetrahydrofuran / 0.25 h

12.1: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 4 h

13.1: CF₃CO₂H / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; tin(II) acetate; sulfur trioxide pyridine complex; sodium hydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2-methoxy-ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo034837z

Reference yield:

: 630046-94-5
methyl (2SR,5S)-5-[N-(tert-butoxycarbonyl)amino]-2-cyano-7-methyl-4-oxooctanoate

: 713497-10-0
[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: NaBH₄ / methanol; 2-methoxy-ethanol / 0.33 h

1.2: 51 percent / DMAP / CH₂Cl₂ / 24 h

2.1: 89 percent / Sn(OAc)2; (i-Pr)2NEt / dimethylformamide / 17 h / 80 °C

3.1: H₂; AcOH / PtO₂ / 5 h / 20 °C

4.1: 59 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 3 h

5.1: 96 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide / 48 h

6.1: 82 percent / AcOH / H₂O / 96 h / 25 °C

7.1: 79 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂; dimethylformamide / 3 h

8.1: HCl / dioxane; H₂O / 2 h

9.1: HATU; (i-Pr)2NEt / dimethylformamide / 20 h

10.1: Et₂NH / Pd(PPh₃)4 / tetrahydrofuran / 0.25 h

11.1: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 4 h

12.1: CF₃CO₂H / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; tin(II) acetate; sulfur trioxide pyridine complex; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 2-methoxy-ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo034837z

Reference yield:

: 10466-61-2
(2S)-amino-4-methylpentanamide hydrochloride

: 713497-10-0
[(2R,3S,7R,10S,13S)-13-((S)-2-Amino-3-methyl-butyrylamino)-7-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-10-isobutyl-2-methyl-4,9,12,15-tetraoxo-1-oxa-5,11-diaza-cyclopentadec-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 89 percent / Sn(OAc)2; (i-Pr)2NEt / dimethylformamide / 17 h / 80 °C

2: H₂; AcOH / PtO₂ / 5 h / 20 °C

3: 59 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 3 h

4: 96 percent / sulfur trioxide pyridine complex; triethylamine / dimethylsulfoxide / 48 h

5: 82 percent / AcOH / H₂O / 96 h / 25 °C

6: 79 percent / 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂; dimethylformamide / 3 h

7: HCl / dioxane; H₂O / 2 h

8: HATU; (i-Pr)2NEt / dimethylformamide / 20 h

9: Et₂NH / Pd(PPh₃)4 / tetrahydrofuran / 0.25 h

10: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / 4 h

11: CF₃CO₂H / CH₂Cl₂ / 2 h

With hydrogenchloride; dmap; hydrogen; tin(II) acetate; sulfur trioxide pyridine complex; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jo034837z