4-bromo-2-aminobenzoic acid piperidine amide

Base Information

• Chemical Name: 4-bromo-2-aminobenzoic acid piperidine amide
• CAS No.: 791098-10-7
• Molecular Formula: C₁₂H₁₅BrN₂O
• Molecular Weight: 283.168
• Mol file: 791098-10-7.mol

Synonyms:4-bromo-2-aminobenzoic acid piperidine amide

Chemical Property of 4-bromo-2-aminobenzoic acid piperidine amide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-bromo-2-aminobenzoic acid piperidine amide

There total 1 articles about 4-bromo-2-aminobenzoic acid piperidine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(2-nitro-4-bromobenzoyl)piperidine (791098-09-4) → 4-bromo-2-aminobenzoic acid piperidine amide (791098-10-7)

Guidance literature:

With tin(ll) chloride; In dichloromethane; ethyl acetate; at 20 ℃; for 12h;

DOI:10.1021/jm060590x

Reference yield: 100.0%

4-bromo-2-aminobenzoic acid piperidine amide (791098-10-7) + C7H4ClNO2S2 (149575-66-6) → benzothiazole-7-sulfonic acid [5-bromo-2-(piperidine-1-carbonyl)-phenyl]-amide (1033464-72-0)

Guidance literature:

With pyridine; In dichloromethane; at 23 ℃;

DOI:10.1016/j.bmc.2008.01.059

Reference yield: 96.0%

4-bromo-2-aminobenzoic acid piperidine amide (791098-10-7) + 4-methyl-3-nitrobenzenesulfonyl chloride (616-83-1) → N-[5-Bromo-2-(piperidine-1-carbonyl)-phenyl]-4-methyl-3-nitro-benzenesulfonamide

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1016/j.bmcl.2007.09.087

upstream raw materials:

1-(2-nitro-4-bromobenzoyl)piperidine

Refernces

• 1、 Allison, Brett D.,Phuong, Victor K.,McAtee, Laura C.,Rosen, Mark,Morton, Magda,Prendergas, Clodagh,Barrett, Terry,Lagaud, Guy,Freedman, Jamie,Li, Na,Wu, Xiaodong,Venkatesan, Hariharan,Pippel, Marna,Woods, Craig,Rizzolio, Michèle C.,Hack, Michael,Hoey, Kenway,Deng, Xiaohu,King, Christopher,Shankley, Nigel P.,Rabinowitz, Michael H.. "Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists". . p. 6371 - 6390. Retrieved 2008/04/18.