[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

Base Information

Chemical Name:[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester
CAS No.:1026013-69-3
Molecular Formula:C₃₁H₄₆N₂O₆
Molecular Weight:542.716
Hs Code.:

[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

Synonyms:[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

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Chemical Property of [3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

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Technology Process of [3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

There total 5 articles about [3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127980-38-5
<1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester

: 130776-17-9
N-(4-cyclohexylbutyl)-L-serinamide

: 1026013-69-3
[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃;
DOI:10.1021/jm00062a013

Reference yield:

4-cyclohexyl-1-butanamine hydrochloride: 91342-30-2
4-cyclohexyl-1-butanamine hydrochloride

: 1026013-69-3
[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxybenzotriazole, 4-methylmorpholine, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / Ambient temperature

2: 12.7 g / trifluoroacetic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00062a013

Reference yield:

: 127980-37-4
{3-[2-((1S,2R,3R,4R)-3-Acetoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid methyl ester

: 1026013-69-3
[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, MeOH / acetone / 0 °C

2: diethyl ether / 25 °C

3: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

With methanol; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00062a013