N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide
CAS No.:1383452-25-2
Molecular Formula:C₂₃H₁₉FN₄O₃
Molecular Weight:418.427
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

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Chemical Property of N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

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Technology Process of N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

There total 9 articles about N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1383452-17-2
N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-1,2,3,4-tetrahydroquinazoline-6-carboxamide

: 1383452-25-2
N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

Guidance literature:: With iodine; In ethanol; at 20 ℃; for 9h; Reflux;
DOI:10.1016/j.ejmech.2012.04.010

Reference yield:

: 1383452-11-6
N₁-(4-fluorobenzyl)-2-methoxy-N₃-methyl-4-pivalamidoiso-phthalamide

: 1383452-25-2
N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 1 h / Reflux

1.2: 0 °C / pH 9 - 10

2.1: magnesium sulfate; toluene-4-sulfonic acid / ethanol / 3 h / Reflux

3.1: iodine / ethanol / 9 h / 20 °C / Reflux

With hydrogenchloride; iodine; magnesium sulfate; toluene-4-sulfonic acid; In ethanol; water;
DOI:10.1016/j.ejmech.2012.04.010

Reference yield:

: 1312305-91-1
N-(3-hydroxy-4-methylphenyl)-2,2-dimethylpropionamide

: 1383452-25-2
N-(4-fluorobenzyl)-5-methoxy-3-methyl-4-oxo-2-(pyridin-2-yl)-3,4-dihydroquinazoline-6-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 20 °C / Inert atmosphere; Reflux

1.2: 1 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 10 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

2.3: 0 °C / pH 2 - 3

3.1: triethylamine / tetrahydrofuran / 2 h / -15 °C

4.1: tetrahydrofuran; water / -15 - 60 °C

5.1: pyridine; potassium permanganate / water / 3 h / 45 - 50 °C

5.2: 0 °C / pH 1 - 2

6.1: triethylamine / tetrahydrofuran / 1 h / -15 °C

7.1: tetrahydrofuran / -15 - 60 °C

8.1: hydrogenchloride / water / 1 h / Reflux

8.2: 0 °C / pH 9 - 10

9.1: magnesium sulfate; toluene-4-sulfonic acid / ethanol / 3 h / Reflux

10.1: iodine / ethanol / 9 h / 20 °C / Reflux

With pyridine; hydrogenchloride; potassium permanganate; n-butyllithium; iodine; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; ethanol; hexane; water; mineral oil;
DOI:10.1016/j.ejmech.2012.04.010