(R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Base Information

• Chemical Name: (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone
• CAS No.: 175553-29-4
• Molecular Formula: C₂₁H₂₆FNO₃
• Molecular Weight: 359.441
• Mol file: 175553-29-4.mol

Synonyms:(R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Chemical Property of (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone

There total 4 articles about (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

R-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (139290-65-6) → (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone (175553-29-4)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at 67 ℃; for 24h;

DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S

Reference yield:

(2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol (139290-69-0) → (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone (175553-29-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 165 mg / DCC; DMAP / CHCl₃ / 15 h / 68 °C

2: 73 percent / K₂CO₃; H₂O / 21 h / 22 °C

3: 65 percent / L-selectride / tetrahydrofuran / 24 h / 67 °C

With dmap; water; L-Selectride; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; 1: Esterification / 2: Hydrolysis / 3: Reduction;

DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S

Reference yield:

(R,S)-(+)-α-[(2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methyl]-α-methoxybenzene acetate → (R)-(+)-α-(2-hydroxy-3-methoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone (175553-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃; H₂O / 21 h / 22 °C

2: 65 percent / L-selectride / tetrahydrofuran / 24 h / 67 °C

With water; L-Selectride; potassium carbonate; In tetrahydrofuran; 1: Hydrolysis / 2: Reduction;

DOI:10.1002/(SICI)1099-1344(199910)42:10<949::AID-JLCR253>3.0.CO;2-S

upstream raw materials:

R-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

(2,3-dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-ethyl]-piperidin-4-yl}-methanol

Downstream raw materials:

R-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol