2-Amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine

Base Information

Chemical Name:2-Amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine
CAS No.:55694-04-7
Molecular Formula:C14H18ClN3O3
Molecular Weight:309.752
Hs Code.:
Nikkaji Number:J267.045C
Mol file:55694-04-7.mol

Synonyms:SCHEMBL11318650;RXLRPQMQLKIIDO-UHFFFAOYSA-N;2-amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine

Suppliers and Price of 2-Amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 8 raw suppliers

Chemical Property of 2-Amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine

Chemical Property:

Vapor Pressure:4.74E-08mmHg at 25°C
Refractive Index:1.573
Boiling Point:443.2 °C at 760 mmHg
PKA:3.51±0.10(Predicted)
Flash Point:221.8 °C
PSA：78.10000
Density:1.3 g/cm³
LogP:2.08630
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:309.0880191
Heavy Atom Count:21
Complexity:310

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2Cl)N

Technology Process of 2-Amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine

There total 3 articles about 2-Amino-4-chloro-5-(3,4,5-trimethoxybenzyl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70311-20-5
3-(3,4,5-trimethoxyphenyl)propionic acid ethyl ester

: 55694-04-7
2-amino-4-chloro-5-(3,4,5-trimethoxybenzyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na / toluene; diethyl ether / 24 h / 0 °C

1.2: 30 percent / NaOMe / methanol / 48 h / Heating

2.1: POCl₃ / 8 h / Heating

With sodium; trichlorophosphate; In diethyl ether; toluene;