9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline

Base Information

• Chemical Name: 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline
• CAS No.: 797017-59-5
• Molecular Formula: C₂₆H₁₈ClFN₂S
• Molecular Weight: 444.96

Synonyms:9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline

Chemical Property of 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline

Chemical Property:

Purity/Quality:

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Technology Process of 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline

There total 3 articles about 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-Mercapto-4-p-fluorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline (128483-25-0) + 4-chlorobenzoylmethyl bromide (536-38-9) → 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline (797017-59-5)

Guidance literature:

With acetic acid; for 5h; Reflux;

DOI:10.1039/c4ra02514h

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline (797017-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: poly(4-vinylpyridinium)hydrogen sulfate / neat (no solvent) / 120 °C

2: acetic acid / 5 h / Reflux

With acetic acid; In neat (no solvent); 1: |Biginelli Pyrimidone Synthesis;

DOI:10.1039/c4ra02514h

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 9-(4-chlorophenyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-benzo-[h]thiazolo[2,3-b]quinazoline (797017-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: poly(4-vinylpyridinium)hydrogen sulfate / neat (no solvent) / 120 °C

2: acetic acid / 5 h / Reflux

With acetic acid; In neat (no solvent); 1: |Biginelli Pyrimidone Synthesis;

DOI:10.1039/c4ra02514h

upstream raw materials:

2-Mercapto-4-p-fluorophenyl-4H-1,2,3,4,5,6-hexahydrobenzo-quinazoline

4-chlorobenzoylmethyl bromide

3,4-dihydronaphthalene-1(2H)-one

4-fluorobenzaldehyde

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