5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

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Chemical Name:5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate
CAS No.:1333380-22-5
Molecular Formula:C₃₇H₃₀N₂O₈
Molecular Weight:630.654
Hs Code.:

5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

Synonyms:5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

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Chemical Property of 5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

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Technology Process of 5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

There total 2 articles about 5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1333380-20-3
(S,E)-benzyl 3-(2-(3-(benzo[d][1,3]dioxol-5-yl)-N-benzylacrylamido)-3-methoxy-3-oxopropyl)-5-hydroxy-1H-indole-1-carboxylate

: 1333380-22-5
5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

Guidance literature:: With bis-[(trifluoroacetoxy)iodo]benzene; In 1,1,1,3',3',3'-hexafluoro-propanol; at 20 ℃; for 4h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol2021669

Reference yield:

: C₅₃H₅₀N₂O₈Si

: 1333380-22-5
5-benzyl 8-methyl (1R,8S,10aR)-1-(benzo[d][1,3]dioxol-5-yl)-9-benzyl-10-oxo-8,9,10,10a-tetrahydro-1H-2-oxa-5,9-diazacycloocta[jkl]-as-indacene-5,8(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride

2: bis-[(trifluoroacetoxy)iodo]benzene / 1,1,1,3',3',3'-hexafluoro-propanol / 4 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; bis-[(trifluoroacetoxy)iodo]benzene; In 1,1,1,3',3',3'-hexafluoro-propanol;
DOI:10.1021/ol2021669