ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate

Base Information

• Chemical Name: ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate
• CAS No.: 453511-36-9
• Molecular Formula: C₁₂H₁₄N₄O₃S₂
• Molecular Weight: 326.4
• Mol file: 453511-36-9.mol

Synonyms:ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate

Chemical Property of ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate

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Technology Process of ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate

There total 10 articles about ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

diethyl 2-isothiocyanato-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylate (258330-01-7) → ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate (453511-36-9)

Guidance literature:

With hydrazine hydrate; In benzene; for 8h; Heating;

DOI:10.1080/10426500211720 DOI:10.1080/10426500210671 DOI:10.1080/10426500307796

Reference yield: 83.0%

3-amino-1,2,3,4,5,6,7,8-octahydro-2,4-dioxopyrido[3',4',4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid ethyl ester (853896-52-3) → ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate (453511-36-9)

Guidance literature:

With pyridine; tetraphosphorus decasulfide; for 6h; Heating;

DOI:10.1080/104265090507812

Reference yield: 78.0%

ethyl 3-(2-(ethoxycarbonyl)hydrazinyl)-4-oxo-2-thioxo-1,2,3,4,5,6-hexahydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-7(8H)carboxylate → ethyl 3-amino-4-oxo-2-thioxo-1,3,4,5,6,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(2H)-carboxylate (453511-36-9)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Reflux;

DOI:10.1002/jhet.3560

upstream raw materials:

diethyl 2-isothiocyanato-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylate

diethyl 2-[(ethoxythioxomethyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3,6-dicarboxylate

3-amino-1,2,3,4,5,6,7,8-octahydro-2,4-dioxopyrido[3',4',4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid ethyl ester

2-amino-3-carbethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyrido-6-carboxylic acid ethyl ester

Downstream raw materials:

ethyl 3-amino-2-[cyanomethylthio]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

ethyl 3-amino-2-[(2-ethoxy-2-oxoethyl)sulfanyl]-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

ethyl 3-amino-2-{[2-phenyl-2-oxoethyl]sulfanyl}-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

ethyl 3-amino-2-{[2-(4-bromophenyl)-2-oxoethyl]sulfanyl}-4-oxo-3,5,6,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(4H)-carboxylate

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