N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

Base Information

Chemical Name:N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide
CAS No.:1181766-49-3
Molecular Formula:C₂₉H₃₅ClN₆O₂
Molecular Weight:535.089
Hs Code.:

Synonyms:N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

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Chemical Property of N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

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Technology Process of N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

There total 5 articles about N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 1181767-95-2
C₂₃H₃₂ClN₅O

: 1181766-49-3
N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; at 20 ℃; for 3h;

Reference yield:

: 1181767-61-2
C₁₅H₂₂N₄O₄

: 1181766-49-3
N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 20 °C

2: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C / 1810.07 Torr

3: N-ethyl-N,N-diisopropylamine; HATU / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; diisopropyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 3644-18-6
N-(2-(dimethylamino)ethyl)piperazine

: 1181766-49-3
N-{5-[2-(3-chloro-phenyl)-ethylcarbamoyl]-2-[4-(2-dimethylamino-ethyl)-piperazin-1-yl]-phenyl}-isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 2 h / 100 °C

2: benzotriazol-1-ol; diisopropyl-carbodiimide / N,N-dimethyl-formamide / 2 h / 20 °C

3: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C / 1810.07 Torr

4: N-ethyl-N,N-diisopropylamine; HATU / 3 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; diisopropyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;