7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Base Information

Chemical Name:7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one
CAS No.:1390655-92-1
Molecular Formula:C₂₅H₂₃Cl₂FN₆O
Molecular Weight:513.402
Hs Code.:

Synonyms:7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

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Chemical Property of 7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

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Technology Process of 7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

There total 17 articles about 7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1390655-92-1
7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: thionyl chloride / 5 h / 20 °C / Cooling with ice

2.1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 80 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: toluene-4-sulfonic acid / toluene; methanol / 2 h / Reflux

5.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: 1,4-dioxane / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 18 h / 120 °C / Sealed tube

10.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

11.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With n-butyllithium; thionyl chloride; sodium tris(acetoxy)borohydride; Dess-Martin periodane; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; toluene;

Reference yield:

: 1390657-53-0
tert-butyl 4-(4-(7-(2,6-dichlorobenzyl)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-ylamino)-5-fluoro-2-methylphenyl)piperazine-1-carboxylate

: 1390655-92-1
7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 1390655-92-1
7-(2,6-dichlorobenzyl)-5-{[2-fluoro-5-methyl-4-(piperazin-1-yl)phenyl]amino}pyrido[3,4-d]pyridazin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; ethylene dibromide / tetrahydrofuran / 0.5 h / 65 °C / Inert atmosphere

1.2: 2.33 h

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / 70 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With chloro-trimethyl-silane; ethylene dibromide; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;