8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

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Chemical Name:8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione
CAS No.:357638-64-3
Molecular Formula:C₂₆H₂₄N₄O₇
Molecular Weight:504.499
Hs Code.:

Synonyms:8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

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Chemical Property of 8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

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Technology Process of 8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

There total 3 articles about 8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 5843-43-6
phenyl isocyanatoformate

: 357638-62-1
1-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)-2-aminoimidazole

: 357638-64-3
8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

Guidance literature:: In 1,4-dioxane; at 20 ℃; for 8h;
DOI:10.1021/jo005743h

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 357638-64-3
8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / potassium carbonate; tris[2-(2-methoxyethoxy)ethyl]amine / acetonitrile / 2 h / 20 °C

2: 0.50 g / hydrogen / Pd-C / methanol / 8 h / 20 °C / 760.05 Torr

3: 55 percent / dioxane / 8 h / 20 °C

With Tris(3,6-dioxaheptyl)amine; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; acetonitrile; 1: Vorbrueggen ribosylation;
DOI:10.1021/jo005743h

Reference yield:

: 357638-60-9
1-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)-2-nitroimidazole

: 357638-64-3
8-(β-D-2'-deoxy-3',5'-bis(4-toluoyloxy)ribofuranosyl)imidazo[1,2-a]-1,3,5-triazine-2(8H),4(3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 0.50 g / hydrogen / Pd-C / methanol / 8 h / 20 °C / 760.05 Torr

2: 55 percent / dioxane / 8 h / 20 °C

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1021/jo005743h