(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Base Information

Chemical Name:(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid
CAS No.:129365-49-7
Molecular Formula:BrH*C₂₃H₃₁N₂O₅P
Molecular Weight:527.395
Hs Code.:

Synonyms:(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

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Chemical Property of (+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Chemical Property:

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Technology Process of (+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

There total 4 articles about (+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[3-(Diethoxy-phosphoryl)-propyl]-1-(3,3-diphenyl-propyl)-piperazine-2-carboxylic acid

: 129365-49-7
(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Guidance literature:: With trimethylsilyl bromide; In acetonitrile; at 25 ℃; for 24h; Yield given;
DOI:10.1021/jm00172a037

Reference yield:

: 126937-45-9
2-methyl 1-(phenylmethyl) (+/-)-4-<3-(diethoxyphosphinyl)propyl>-1,2-piperazinedicarboxylate

: 129365-49-7
(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / H₂ / 20percent Pd/C / methanol / 18 h

2: 71 percent / Na₂CO₃ / ethanol / 72 h / Heating

3: 4 M aq. NaOH / methanol / 18 h / 25 °C

4: (CH₃)3SiBr / acetonitrile / 24 h / 25 °C

With sodium hydroxide; trimethylsilyl bromide; hydrogen; sodium carbonate; palladium on activated charcoal; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm00172a037

Reference yield:

: 129365-29-3
methyl (+/-)-4-<3-(diethoxyphosphinyl)propyl>-2-piperazinecarboxylate

: 129365-49-7
(+/-)-1-(3,3-diphenylpropyl)-4-(3-phosphonopropyl)-2-piperazinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / Na₂CO₃ / ethanol / 72 h / Heating

2: 4 M aq. NaOH / methanol / 18 h / 25 °C

3: (CH₃)3SiBr / acetonitrile / 24 h / 25 °C

With sodium hydroxide; trimethylsilyl bromide; sodium carbonate; In methanol; ethanol; acetonitrile;
DOI:10.1021/jm00172a037