5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione
CAS No.:135481-60-6
Molecular Formula:C₁₈H₂₃N₃O₂
Molecular Weight:313.4
Hs Code.:

Synonyms:5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

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Technology Process of 5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

There total 4 articles about 5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 135481-56-0
5,7-dihydro-6-phenylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

: 106-94-5
propyl bromide

: 135481-60-6
5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With sodium hydroxide; tetrabutylammomium bromide; In toluene; at 60 ℃; for 48h;
DOI:10.1021/jm00113a032

Reference yield:

: 135481-41-3
N-(2-cyanoethyl)-N-(cyanonmethyl)aniline

: 135481-60-6
5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1: KOt-Bu / 2-methyl-propan-2-ol

2: 1.) NaOEt / 1.) ethanol, reflux, 1 h, 2.) reflux, 2 h

3: 95 percent / 3 N aq. HCl / 4 h / Heating

4: 29 percent / 10percent NaOH, tetrabutylammonium bromide / toluene / 48 h / 60 °C

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; tetrabutylammomium bromide; sodium ethanolate; In toluene; tert-butyl alcohol;
DOI:10.1021/jm00113a032

Reference yield:

: 23935-82-2
4-amino-1-phenyl-2,5-dihydro-pyrrole-3-carbonitrile

: 135481-60-6
5,7-dihydro-6-phenyl-1,3-di-n-propylpyrrolo<3,4-d>pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOEt / 1.) ethanol, reflux, 1 h, 2.) reflux, 2 h

2: 95 percent / 3 N aq. HCl / 4 h / Heating

3: 29 percent / 10percent NaOH, tetrabutylammonium bromide / toluene / 48 h / 60 °C

With hydrogenchloride; sodium hydroxide; tetrabutylammomium bromide; sodium ethanolate; In toluene;
DOI:10.1021/jm00113a032