(1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

Base Information

Chemical Name:(1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]
CAS No.:889888-75-9
Molecular Formula:C₂₁H₃₂N₂O₄
Molecular Weight:376.496
Hs Code.:

Synonyms:(1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

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Chemical Property of (1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

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Technology Process of (1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

There total 6 articles about (1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 889888-74-8
(1S,2S)-2-[2'-hydroxy-1'-(S)-tert-butylethylcarbamoyl]-cyclopentane-1-carboxylic acid

: 56613-80-0
D-2-phenylglycinol

: 889888-75-9
(1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; at 20 ℃; for 120h;
DOI:10.1016/j.tetasy.2005.12.036

Reference yield:

: (1S,2S)-2-Chlorocarbonyl-cyclopentanecarboxylic acid methyl ester

: 889888-75-9
(1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

Guidance literature:: Multi-step reaction with 3 steps

1: 6.582 g / triethylamine / CH₂Cl₂ / 0 - 20 °C

2: 95 percent / sodium hydroxide / methanol; H₂O / 4 h / 20 °C

3: 86 percent / 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / tetrahydrofuran / 120 h / 20 °C

With sodium hydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.tetasy.2005.12.036

Reference yield:

: 889888-72-6
(1S,2S)-2-[2'-hydroxy-1'-(S)-tert-butylethylcarbamoyl]-cyclopentane-1-carboxylic acid methyl ester

: 889888-75-9
(1S,2S)-cyclopentane-1,2-dicarboxylic acid 1-[(2'-hydroxy-1'-(S)-tert-butylethyl)-amide]-2-[(2''-hydroxy-1''-(R)-phenylethyl)-amide]

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / sodium hydroxide / methanol; H₂O / 4 h / 20 °C

2: 86 percent / 1-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / tetrahydrofuran / 120 h / 20 °C

With sodium hydroxide; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.tetasy.2005.12.036