4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

Base Information

Chemical Name:4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide
CAS No.:280117-16-0
Molecular Formula:C₂₅H₁₈N₆O₄S
Molecular Weight:498.522
Hs Code.:

4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-<i>d</i>]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

Synonyms:4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

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Chemical Property of 4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

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Technology Process of 4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

There total 12 articles about 4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 903876-78-8
4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid tert-butylamide

: 280117-16-0
4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 280119-44-0
Methyl (1-[4-Methoxyphenyl]-3-cyano-4-amino)pyrazole-5-carboxylate

: 280117-16-0
4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaNO₂; TFA / 0 °C

1.2: 75 percent / NaN₃

2.1: aq. LiOH / tetrahydrofuran

3.1: (COCl)2 / CH₂Cl₂

4.1: CH₂Cl₂

5.1: SnCl₂*2H₂O / 65 °C

6.1: H₂O / Heating

7.1: Pd(Ph₃P)4; aq. Na₂CO₃ / benzene / 80 °C

8.1: aq. NH₃ / dioxane / 80 °C

9.1: 50 percent / POCl₃ / benzene / Heating

10.1: TFA / CH₂Cl₂ / 25 °C

With lithium hydroxide; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; sodium carbonate; trifluoroacetic acid; tin(ll) chloride; sodium nitrite; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene; 7.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.044

Reference yield:

: 4-azido-5-cyano-2-(4-methoxy-phenyl)-2H-pyrazole-3-carbonyl chloride

: 280117-16-0
4'-[3-cyano-1-(4-methoxy-phenyl)-7-oxo-1,7-dihydro-pyrazolo[4,3-d]pyrimidin-6-yl]-biphenyl-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: CH₂Cl₂

2: SnCl₂*2H₂O / 65 °C

3: H₂O / Heating

4: Pd(Ph₃P)4; aq. Na₂CO₃ / benzene / 80 °C

5: aq. NH₃ / dioxane / 80 °C

6: 50 percent / POCl₃ / benzene / Heating

7: TFA / CH₂Cl₂ / 25 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; tin(ll) chloride; trichlorophosphate; In 1,4-dioxane; dichloromethane; water; benzene; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2006.04.044