1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Base Information

• Chemical Name: 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine
• CAS No.: 1448317-21-2
• Molecular Formula: C₂₁H₂₅N₅O₄
• Molecular Weight: 411.461

Synonyms:1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Chemical Property of 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

There total 3 articles about 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-bromo-4-nitrotoluene (7745-93-9) + 1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine (222056-48-6) → 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine (1448317-21-2)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 4h; Inert atmosphere; Reflux;

Reference yield:

nicotinoylacetonitrile (30510-18-0) → 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine (1448317-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 4 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

With hydrogenchloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water;

Reference yield:

hydrazinoacetaldehyde diethyl acetal (42351-81-5) → 1-(2,2-diethoxyethyl)-N-(2-methyl-5-nitrophenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine (1448317-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 4 h / Reflux

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 4 h / Inert atmosphere; Reflux

With hydrogenchloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; water;

upstream raw materials:

nicotinoylacetonitrile

2-bromo-4-nitrotoluene

1-(2,2-diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

hydrazinoacetaldehyde diethyl acetal

Downstream raw materials:

2-methoxy-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(penta-fluoro-λ⁶-sulphanyl)benzamide

3-bromo-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pentafluoro-λ⁶-sulphanyl)benzamide

N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(trifluoromethyl)-benzamide

N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-3-(pentafluoro-λ⁶-sulphanyl)-5-(piperazin-1-ylmethyl)benzamide

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