1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

Base Information

• Chemical Name: 1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione
• CAS No.: 128721-62-0
• Molecular Formula: C₃₃H₂₈N₂O₅S
• Molecular Weight: 564.662
• Mol file: 128721-62-0.mol

Synonyms:1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

Chemical Property of 1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

There total 2 articles about 1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,3-bis-(2-methoxy-phenyl)-2-thio-barbituric acid (85788-85-8) + 1,3-diphenyl-propen-3-one (614-47-1) → 1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (128721-62-0)

Guidance literature:

With aluminum oxide; at 90 - 120 ℃; for 0.025h; microwave irradiation;

DOI:10.1081/SCC-120005424

Reference yield: 60.0%

1,3-bis-(2-methoxy-phenyl)-2-thio-barbituric acid (85788-85-8) + benzalacetophenone (94-41-7) → 1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (128721-62-0)

Guidance literature:

With triethylamine; In methanol; for 5h; Heating;

Reference yield: 89.0%

1,3-Bis-(2-methoxy-phenyl)-5-(3-oxo-1,3-diphenyl-propyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (128721-62-0) → 1,3-Bis-(2-methoxy-phenyl)-5,7-diphenyl-2-thioxo-1,2,3,5-tetrahydro-pyrano[2,3-d]pyrimidin-4-one (128747-08-0)

Guidance literature:

With Montmorillonite; at 90 - 120 ℃; for 0.04h; microwave irradiation;

DOI:10.1081/SCC-120005424

upstream raw materials:

1,3-bis-(2-methoxy-phenyl)-2-thio-barbituric acid

benzalacetophenone

1,3-diphenyl-propen-3-one

Downstream raw materials:

1,3-Bis-(2-methoxy-phenyl)-5,7-diphenyl-2-thioxo-1,2,3,5-tetrahydro-pyrano[2,3-d]pyrimidin-4-one