3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

Base Information

Chemical Name:3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone
CAS No.:915038-37-8
Molecular Formula:C₂₁H₁₈O₅S
Molecular Weight:382.437
Hs Code.:

Synonyms:3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

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Chemical Property of 3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

Chemical Property:

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Technology Process of 3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

There total 4 articles about 3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [4-(3-hydroxy-but-1-ynyl)-phenyl]-acetic acid 2-(4-methanesulfonyl-phenyl)-2-oxo-ethyl ester

: 915038-37-8
3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In acetonitrile; at 0 ℃; for 0.833333h;
DOI:10.1016/j.bmc.2006.07.047

Reference yield:

: 1798-06-7
(4-iodophenyl)acetic acid

: 915038-37-8
3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / cuprous iodide; triethylamine / dichlorobis(triphenylphosphine)palladium / 50 °C

2: triethylamine / acetonitrile / 0.5 h / 25 °C

3: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.83 h / 0 °C

With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; 1: Sonogashira coupling;
DOI:10.1016/j.bmc.2006.07.047

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 915038-37-8
3-[4-(3-hydroxybut-1-ynyl)phenyl]-4-(4-methanesulfonylphenyl)-2(5H)furanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium nitrite; sulfuric acid / H₂O / 0.5 h / 0 °C

1.2: 69 percent / KI / H₂O / 2.5 h / 0 °C

2.1: 91 percent / cuprous iodide; triethylamine / dichlorobis(triphenylphosphine)palladium / 50 °C

3.1: triethylamine / acetonitrile / 0.5 h / 25 °C

4.1: triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.83 h / 0 °C

With copper(l) iodide; sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; 2.1: Sonogashira coupling;
DOI:10.1016/j.bmc.2006.07.047