2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Base Information

Chemical Name:2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide
CAS No.:147313-49-3
Molecular Formula:C₃₃H₄₁ClF₃N₃O₅Si
Molecular Weight:680.239
Hs Code.:

2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Synonyms:2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Chemical Property of 2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

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Technology Process of 2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

There total 10 articles about 2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 147269-05-4
N-(2-tert-Butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropyl-propyl)-2-iodoacetamide

: 147313-48-2
benzyl 6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate

: 147313-49-3
2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

Guidance literature:: With nitrogen; In hydrogenchloride; mineral oil;

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 147313-49-3
2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: [2-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methoxy}-6-(2-chloro-phenyl)-pyridin-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane / 12 h

2: sodium iodide / acetone / 12 h / Ambient temperature

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

With 2,6-dimethylpyridine; sodium hydride; sodium iodide; In dichloromethane; acetone;
DOI:10.1021/jm00046a015

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 147313-49-3
2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide

: [2-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methoxy}-6-(2-chloro-phenyl)-pyridin-3-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine / tetrahydrofuran / 12 h

2: 2,6-dimethylpyridine / dichloromethane / 12 h

3: sodium iodide / acetone / 12 h / Ambient temperature

4: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydride; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jm00046a015