2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene

Base Information

• Chemical Name: 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene
• CAS No.: 148324-47-4
• Molecular Formula: C₂₂H₁₈O₄
• Molecular Weight: 346.383
• Mol file: 148324-47-4.mol

Synonyms:2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene

Chemical Property of 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene

There total 3 articles about 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene (148324-45-2) → 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene (148324-47-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1016/j.tet.2003.09.046

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene (148324-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / sodium ethoxide / ethanol / 24 h / Heating

2: 94 percent / KOH / ethanol / 24 h / Heating

With potassium hydroxide; sodium ethanolate; In ethanol; 1: Wittig reaction;

DOI:10.1016/j.tet.2003.09.046

Reference yield:

(3-acetyloxy-2-ethoxycarbonylbenzyl)-triphenylphosphonium bromide (118842-88-9) → 2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene (148324-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / sodium ethoxide / ethanol / 24 h / Heating

2: 94 percent / KOH / ethanol / 24 h / Heating

With potassium hydroxide; sodium ethanolate; In ethanol; 1: Wittig reaction;

DOI:10.1016/j.tet.2003.09.046

upstream raw materials:

2-(4'-benzyloxyphenyl)-1-(3-hydroxy-2-ethoxycarbonylphenyl)ethene

p-benzyloxybenzaldehyde

(3-acetyloxy-2-ethoxycarbonylbenzyl)-triphenylphosphonium bromide

Downstream raw materials:

hydrangenol

3-(4'-benzyloxyphenyl)-8-hydroxy-3,4-dihydro-2-benzopyran-1-one