tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate
CAS No.:1404115-29-2
Molecular Formula:C₁₈H₂₁F₂N₃O₃
Molecular Weight:365.38
Hs Code.:

Synonyms:tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

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Chemical Property of tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

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Technology Process of tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

There total 5 articles about tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.2%

: 143250-10-6
2-bromo-5-methoxypyrazine

: tert-butyl 2,2-difluoro-2-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamate

: 1404115-29-2
tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In water; at 120 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield:

: 583-55-1
1-Bromo-2-iodobenzene

: 1404115-29-2
tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: Cu bronze / dimethyl sulfoxide / Heating

2.1: ammonia / methanol / 1 h / 21 °C

3.1: borane-THF / tetrahydrofuran / 2.5 h / Reflux; Inert atmosphere

3.2: 2 h / 50 °C / Inert atmosphere

3.3: 20 °C / pH 10

4.1: triethylamine / dichloromethane / 0.75 h / 21 °C

5.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 4 h / Inert atmosphere; Heating

6.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water / 0.67 h / 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; borane-THF; ammonia; potassium acetate; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; 5.1: |Suzuki Coupling / 6.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031

Reference yield:

: 1404115-27-0
2-(2-bromophenyl)-2,2-difluoroethanamine

: 1404115-29-2
tert-butyl 2,2-difluoro-2-(2-(5-methoxypyrazin-2-yl)phenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.75 h / 21 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 4 h / Inert atmosphere; Heating

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water / 0.67 h / 120 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki Coupling / 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.08.031