methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Base Information

Chemical Name:methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate
CAS No.:1372540-66-3
Molecular Formula:C₂₂H₂₁ClF₃N₃O₃
Molecular Weight:467.875
Hs Code.:

Synonyms:methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

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Chemical Property of methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

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Technology Process of methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

There total 6 articles about methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 1372540-66-3
methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate; N-methoxylamine hydrochloride / copper diacetate / N,N-dimethyl-formamide / 3 h / 0 °C / Inert atmosphere

1.2: pH 1

2.1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

4.1: hydrogen / palladium on activated charcoal / methanol / 3 h / 20 °C / 3040.2 Torr / autoclave

5.1: N,N-dimethyl-formamide / 4 h / 170 °C

6.1: trichlorophosphate; N,N-dimethyl-aniline / 12 h / 103 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With potassium tert-butylate; hydrogen; N-methoxylamine hydrochloride; potassium carbonate; N,N-dimethyl-aniline; triethylamine; HATU; trichlorophosphate; palladium on activated charcoal; copper diacetate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 193481-78-6
3-Amino-5-chloro-2-nitrobenzoic acid

: 1372540-66-3
methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; HATU / tetrahydrofuran / 3 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

3: hydrogen / palladium on activated charcoal / methanol / 3 h / 20 °C / 3040.2 Torr / autoclave

4: N,N-dimethyl-formamide / 4 h / 170 °C

5: trichlorophosphate; N,N-dimethyl-aniline / 12 h / 103 °C

6: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With hydrogen; potassium carbonate; N,N-dimethyl-aniline; triethylamine; HATU; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 874301-23-2
3-amino-5-chloro-2-nitrobenzoic acid methyl ester

: 1372540-66-3
methyl 2-chloro-1-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-6-(4-morpholinyl)-1H-benzimidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 110 °C

2: hydrogen / palladium on activated charcoal / methanol / 3 h / 20 °C / 3040.2 Torr / autoclave

3: N,N-dimethyl-formamide / 4 h / 170 °C

4: trichlorophosphate; N,N-dimethyl-aniline / 12 h / 103 °C

5: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

With hydrogen; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;