(alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Base Information

Chemical Name:(alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol
CAS No.:1195186-11-8
Molecular Formula:C₂₀H₁₉ClF₄N₄O
Molecular Weight:442.844
Hs Code.:

Synonyms:(alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Suppliers and Price of (alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

There total 4 articles about (alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.81%

: 1195190-25-0
[5-(2-chloro-6-methyl-4-pyridinyl)-1-[(3S)-3-hydroxybutyl]-1H-pyrazol-3-yl][4-fluoro-3-(trifluoromethyl)phenyl]-carbamic acid 1,1-dimethylethyl ester

: 1195186-11-8
(alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Guidance literature:: [5-(2-chloro-6-methyl-4-pyridinyl)-1-[(3S)-3-hydroxybutyl]-1H-pyrazol-3-yl][4-fluoro-3-(trifluoromethyl)phenyl]-carbamic acid 1,1-dimethylethyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1195190-24-9
[5-(2-chloro-6-methyl-4-pyridinyl)-1H-pyrazol-3-yl][4-fluoro-3-(trifluoromethyl)phenyl]-carbamic acid 1,1-dimethylethyl ester

: 1195186-11-8
(alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1195189-95-7
C₁₇H₁₃ClF₄N₂OS

: 1195186-11-8
(alphaS)-5-(2-chloro-6-methyl-4-pyridinyl)-3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1H-pyrazole-1-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / tert-butyl alcohol / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium hydride; caesium carbonate; hydrazine hydrate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;