7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

Base Information

Chemical Name:7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde
CAS No.:858946-66-4
Molecular Formula:C₂₉H₃₉FO₃Si₂
Molecular Weight:510.796
Hs Code.:

Synonyms:7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

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Chemical Property of 7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

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Technology Process of 7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

There total 7 articles about 7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6836-19-7
7-Methoxy-1-tetralone

: 858946-66-4
7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: ZnI₂ / benzene / 20 °C

1.2: POCl₃; pyridine / benzene / 6 h / Heating

2.1: p-cymene / Pd/C / Heating

3.1: 0.88 g / C₆H₅N*HCl / 2 h / 190 °C

4.1: Br₂; acetic acid / 6 h / 100 °C

4.2: aq. HCl; SnCl₂ / 1 h / 100 °C

5.1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

6.1: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

7.1: 7.68 g / imidazole / dimethylformamide

8.1: DIBAL / toluene / -78 - 20 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylisopropylbenzene; C₆H₅N*HCl; bromine; diisobutylaluminium hydride; sodium carbonate; acetic acid; zinc(II) iodide; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; benzene; 5.1: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 158365-53-8
7-methoxy-3,4-dihydronaphthalene-1-carbonitrile

: 858946-66-4
7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: p-cymene / Pd/C / Heating

2.1: 0.88 g / C₆H₅N*HCl / 2 h / 190 °C

3.1: Br₂; acetic acid / 6 h / 100 °C

3.2: aq. HCl; SnCl₂ / 1 h / 100 °C

4.1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

5.1: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

6.1: 7.68 g / imidazole / dimethylformamide

7.1: DIBAL / toluene / -78 - 20 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylisopropylbenzene; C₆H₅N*HCl; bromine; diisobutylaluminium hydride; sodium carbonate; acetic acid; palladium on activated charcoal; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; 4.1: Suzuki coupling;
DOI:10.1021/jm058173s

Reference yield:

: 550998-30-6
3-bromo-7-hydroxy-1-cyanonaphthalene

: 858946-66-4
7-[[tert-butyl(dimethyl)silyl]oxy]-3-(4-[[tert-butyl(dimethyl)silyl]oxy]-3-fluorophenyl)-1-naphthaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: aq. Na₂CO₃; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C

2: 0.085 g / C₆H₅N*HCl / 2 h / 190 °C

3: 7.68 g / imidazole / dimethylformamide

4: DIBAL / toluene / -78 - 20 °C

With 1H-imidazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; C₆H₅N*HCl; diisobutylaluminium hydride; sodium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling;
DOI:10.1021/jm058173s