benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate

Base Information

• Chemical Name: benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate
• CAS No.: 70117-59-8
• Molecular Formula: C₂₈H₃₈N₄O₆
• Molecular Weight: 526.633
• Mol file: 70117-59-8.mol

Synonyms:benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate

Chemical Property of benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate

There total 4 articles about benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

H-L-Lys(Z)-NH2 (61734-68-7) + Boc-Phe-ONSu (3674-06-4) → benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate (70117-59-8)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 deg C, 2 h, 2.) room temp., 24 h;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + H-L-Lys(Z)-NH2 (61734-68-7) → benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate (70117-59-8)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + ((S)-5-Amino-5-carbamoyl-pentyl)-carbamic acid benzyl ester; compound with trifluoro-acetic acid → benzyl ((S)-6-amino-5-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-6-oxohexyl)carbamate (70117-59-8)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(98)80043-3

upstream raw materials:

H-L-Lys(Z)-NH2

Boc-Phe-ONSu

(9S,12S)-methyl 12-benzyl-16,16-dimethyl-3,11,14-trioxo-1-phenyl-2,15-dioxa-4,10,13-triazaheptadecane-9-carboxylate

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

benzyl ((S)-6-amino-5-((S)-2-amino-3-phenylpropanamido)-6-oxohexyl)carbamate