Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester

Base Information

• Chemical Name: Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester
• CAS No.: 479687-09-7
• Molecular Formula: C₂₄H₂₈N₂O₅
• Molecular Weight: 424.497
• Mol file: 479687-09-7.mol

Synonyms:Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester

Chemical Property of Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester

There total 1 articles about Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid (2900-27-8) + (S)-3-benzoyloxypyrrolidine (259184-49-1) → Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester (479687-09-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/b204844b

Reference yield: 80.0%

Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester (479687-09-7) → [(S)-2-((S)-3-Hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

With lithium aluminium tetrahydride; In toluene; at 0 ℃; for 1h;

DOI:10.1039/b204844b

Reference yield: 70.0%

Benzoic acid (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-pyrrolidin-3-yl ester (479687-09-7) → N-Methyl-N[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidine-1-yl)]ethane (142773-73-7)

Guidance literature:

With lithium aluminium tetrahydride; In toluene; at 0 - 80 ℃; for 18h;

DOI:10.1039/b204844b

upstream raw materials:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

(S)-3-benzoyloxypyrrolidine

Downstream raw materials:

N-Methyl-N[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidine-1-yl)]ethane