(3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

Base Information

Chemical Name:(3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid
CAS No.:348624-09-9
Molecular Formula:C₂₀H₂₇N₃O₃
Molecular Weight:357.453
Hs Code.:

Synonyms:(3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

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Technology Process of (3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

There total 2 articles about (3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348624-08-8
tert-butyl (3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoate

: 348624-09-9
(3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 27h;
DOI:10.1021/jm061010z

Reference yield:

: 343251-07-0
(2R)-2-[2-(tert-butoxy)-2-oxoethyl]-5-cyclohexylpentanoic acid

: 348624-09-9
(3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 840 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N-methylmorpholine; 1-hydroxybenzotriazole hydrate / CH₂Cl₂ / 18 h / 20 °C

2: 420 mg / xylene / 4.5 h / 130 °C

3: 390 mg / HCl / dioxane / 27 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; xylene;
DOI:10.1021/jm061010z

Reference yield:

: 348624-09-9
(3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid

: (3R)-6-cyclohexyl-N-hydroxy-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide

Guidance literature:: (3R)-6-cyclohexyl-3-[3-(4-pyridinylmethyl)-1,2,4-oxadiazol-5-yl]hexanoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; for 1h;

With O-Trimethylsilylhydroxylamine; In dichloromethane; for 3.5h;

With methanol; In dichloromethane; at 20 ℃; for 2h; Further stages.;
DOI:10.1021/jm061010z