3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

Base Information

Chemical Name:3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide
CAS No.:926300-93-8
Molecular Formula:C₂₃H₂₉ClF₃N₃O₆S
Molecular Weight:568.014
Hs Code.:

Synonyms:3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

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Chemical Property of 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

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Technology Process of 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

There total 7 articles about 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoic acid

: 122172-59-2
N-pentylsulfamide

: 926300-93-8
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-23-6
ethyl 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]propanoate

: 926300-93-8
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

1.2: 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-62-3
ethyl (2E)-3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(methoxymethoxy)phenyl]acrylate

: 926300-93-8
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-[(pentylamino)sulfonyl]propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

2.1: hydrogenchloride; water / tetrahydrofuran / 0.75 h / 50 °C

3.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 0.08 h / 50 °C

4.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

4.2: 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With hydrogenchloride; dmap; tributylphosphine; palladium 10% on activated carbon; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; ethanol; water; acetonitrile; 3.1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2012.03.036