4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

Base Information

Chemical Name:4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid
CAS No.:448954-09-4
Molecular Formula:C₃₂H₃₄N₂O₆S
Molecular Weight:574.698
Hs Code.:

Synonyms:4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

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Chemical Property of 4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

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Technology Process of 4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

There total 11 articles about 4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 448954-19-6
ethyl 4-[3-(4-{[benzyl(2-methyl-3-(methylsulfonyl))amino]methyl}phenoxy)phenoxy]butanoate

: 448954-09-4
4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2004.06.023

Reference yield:

: 448954-08-3
N-(3-{benzyl[4-(3-hydroxyphenoxy)benzyl]amino}-2-methylphenyl)methanesulfonamide

: 448954-09-4
4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.25 h

1.2: dimethylformamide

2.1: aq. NaOH / tetrahydrofuran; ethanol / 20 °C

With sodium hydroxide; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm050205o

Reference yield:

: 102-29-4
Resorcinol monoacetate

: 448954-09-4
4-(3-{4-[(benzyl{2-methyl-3-[(methylsulfonyl)amino]phenyl}amino)methyl]phenoxy}phenoxy)butanoic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 57 percent / K₂CO₃ / dimethylformamide / 12 h / 80 °C

2: aq. NaOH / tetrahydrofuran; methanol / 1 h / 20 °C

3: K₂CO₃ / dimethylformamide / 12 h / 100 °C

4: AcOH / 1,2-dichloro-ethane / 4 h / 20 °C

5: Na(OAc)3BH / 1,2-dichloro-ethane / 12 °C

6: 84 percent / i-Pr₂NEt / dimethylformamide / 12 h / 90 °C

7: 96 percent / Pd(PPh₃)4; PhSiH₃ / CH₂Cl₂ / 1 h / 20 °C

8: 69 percent / NaH / dimethylformamide / 12 h / 0 - 20 °C

9: Fe; aq. NH₄Cl / ethanol / 1 h / 80 °C

10: pyridine / 1 h / 20 °C

11: 72 percent / NaOH / tetrahydrofuran; ethanol / 2.5 h / 20 °C

With pyridine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; sodium tris(acetoxy)borohydride; iron; sodium hydride; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.06.023