4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

Base Information

Chemical Name:4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide
CAS No.:1189138-93-9
Molecular Formula:C₂₄H₂₅ClN₄O₂
Molecular Weight:436.941
Hs Code.:

Synonyms:4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

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Chemical Property of 4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

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Technology Process of 4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

There total 5 articles about 4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1189135-73-6
4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoic acid

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1189138-93-9
4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 19h;
DOI:10.1016/j.bmc.2012.02.005

Reference yield:

: 1189135-49-6
methyl 4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}benzoate

: 1189138-93-9
4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

1.2: 20 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran; isopropyl alcohol / 19 h / 20 °C

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.02.005

Reference yield:

: 160979-67-9
methyl 4-(2-acetyl-3-oxobutyl)benzoate

: 1189138-93-9
4-{[1-(3-chloro-4-cyanophenyl)-3,5-dimethyl-1H-pyrazol-4-yl]methyl}-N-(2-hydroxy-2-methylpropyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 20 h / 0 - 20 °C

3.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 50 °C

3.2: 20 °C

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran; isopropyl alcohol / 19 h / 20 °C

With sodium hydride; hydrazine hydrate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;
DOI:10.1016/j.bmc.2012.02.005