(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Base Information

Chemical Name:(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate
CAS No.:1383006-26-5
Molecular Formula:C₂HF₃O₂*C₂₆H₂₈N₄O₅
Molecular Weight:590.556
Hs Code.:

Synonyms:(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Suppliers and Price of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

There total 9 articles about (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383006-19-6
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid ethyl ester trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1383006-26-5
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Guidance literature:: (2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid ethyl ester trifluoroacetate; With water; sodium hydroxide; In ethanol; for 1h;

With acetic acid; In ethanol;

trifluoroacetic acid;

Reference yield:

: 128779-47-5
(2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid

: 1383006-26-5
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere

2.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

2.2: 3 h / -5 °C

3.1: toluene / 3 h / Inert atmosphere; Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.25 h / -65 °C / Inert atmosphere

4.2: 2 h / -35 °C

5.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

5.2: 2.25 h / 0 °C

6.1: potassium carbonate / 20 h / 20 °C / Inert atmosphere

7.1: acetyl chloride / ethanol / 3 h / 25 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

9.1: sodium hydroxide; water / ethanol / 1 h

With dmap; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; HATU; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1383026-42-3
[(S)-2-biphenyl-4-yl-1-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylmethyl)ethyl]carbamic acid t-butyl ester

: 1383006-26-5
(2R,4R)-5-biphenyl-4-yl-2-hydroxy-4-{[5-(pyrrolidine-1-carbonyl)-2H-pyrazole-3-carbonyl]amino}pentanoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 3 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

4.2: 0.5 h

5.1: hydrogenchloride / water / 20 h / 90 - 95 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

7.1: sodium hydroxide; water / ethanol / 1 h

With hydrogenchloride; n-butyllithium; water; sodium hexamethyldisilazane; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; hexanes; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;