6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

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Chemical Name:6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one
CAS No.:117818-22-1
Molecular Formula:C₁₈H₁₉N₅O₄
Molecular Weight:369.38
Hs Code.:

Synonyms:6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

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Chemical Property of 6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

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Technology Process of 6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

There total 7 articles about 6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 117818-26-5
6-amino-1-<2'-deoxy-3'-O-(methoxythiocarbonyl)-5'-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

: 117818-22-1
6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 100 ℃; for 2h;
DOI:10.1002/hlca.19880710410

Reference yield:

: 3056-12-0,3601-89-6,4330-21-6,52304-86-6,141846-57-3
2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythropentofuranosyl chloride

: 117818-22-1
6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) KOH, tris<2-(2-methoxyethoxy)ethyl>amine / 1.) MeCN, 30 min., r.t., 2.) H₂O, CH₂Cl₂, 2 h

2: NaOH / Ambient temperature

3: 73 percent / 1,2-dichloro-ethane; pyridine / 3 h / Ambient temperature

4: dimethylformamide / 3 h / 80 °C

5: 2 h / 60 °C

6: 93 percent / 2,2'-azobis(2-methylpropiononitrile), tributylstannane / toluene / 2 h / 100 °C

With potassium hydroxide; sodium hydroxide; 2,2'-azobis(isobutyronitrile); Tris(3,6-dioxaheptyl)amine; tri-n-butyl-tin hydride; In pyridine; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19880710410

Reference yield:

: 117818-24-3
6-amino-1-<2'-deoxy-5'-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

: 117818-22-1
6-amino-1-<2',3'-dideoxy-5'-O-(p-toluoyl)-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 3 h / 80 °C

2: 2 h / 60 °C

3: 93 percent / 2,2'-azobis(2-methylpropiononitrile), tributylstannane / toluene / 2 h / 100 °C

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19880710410