(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester
CAS No.:162878-23-1
Molecular Formula:C₈₀H₁₂₃N₃O₁₄S
Molecular Weight:1382.93
Hs Code.:

(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Synonyms:(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

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Chemical Property of (S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

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Technology Process of (S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

There total 4 articles about (S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 139573-77-6
N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-((R)-2,3-bis(palmitoyloxy)propyl)-L-cysteine

: 162877-54-5
(S)-2-{4-[(tert-Butoxycarbonylmethyl-amino)-methyl]-benzoylamino}-pentanedioic acid di-tert-butyl ester

: 162878-23-1
(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1248/cpb.46.255

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 162878-23-1
(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

2: 67 percent / H₂ / 10percent Pd/C / methanol

3: 87 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

With hydrogen; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.255

Reference yield:

: 162877-56-7
4-(N-benzyloxycarbonyl-N-(t-butyloxycarbonylmethyl)-aminomethyl)benzoic acid

: 162878-23-1
(S)-2-[4-({[(R)-3-((R)-2,3-Bis-hexadecanoyloxy-propylsulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionyl]-tert-butoxycarbonylmethyl-amino}-methyl)-benzoylamino]-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

2: 67 percent / H₂ / 10percent Pd/C / methanol

3: 87 percent / DEPC, Et₃N / dimethylformamide / 1 h / Ambient temperature

With hydrogen; triethylamine; diethyl dicarbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.255