{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

Base Information

Chemical Name:{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine
CAS No.:603962-98-7
Molecular Formula:C₂₁H₃₃F₂NOSi
Molecular Weight:381.581
Hs Code.:

{2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

Synonyms:{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

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Chemical Property of {2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

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Technology Process of {2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

There total 4 articles about {2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 603962-92-1
(2E)-2-[(2R,S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopentylidene]-2-fluoro-N-(4-fluorobenzyl)ethanamide

: 603962-98-7
{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

Guidance literature:: (2E)-2-[(2R,S)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclopentylidene]-2-fluoro-N-(4-fluorobenzyl)ethanamide; With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; at 0 ℃; for 2h;

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃;
DOI:10.1016/S0040-4039(03)01542-9

Reference yield:

: 129600-97-1
2-<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>cyclopentanone

: 603962-98-7
{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / diethyl ether / 0.08 h / -5 °C

1.2: 33 percent / Wadsworth-Horner-Emmons reagent / diethyl ether / 4 h

2.1: 97 percent / aq. KOH / methanol / 8 h / 20 °C

3.1: diisopropylethylamine; TBTU / CH₂Cl₂ / 0.08 h

3.2: 89 percent / CH₂Cl₂ / 3 h

4.1: POCl₃ / CH₂Cl₂ / 1 h / 0 °C

4.2: LiAlH₄ / diethyl ether / 3 h / 0 °C

With potassium hydroxide; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm0495982

Reference yield:

: 140-75-0
para-fluorobenzylamine

: 603962-98-7
{2-[2-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopentylidene]-2-fluoro-ethyl}-(4-fluoro-benzyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine; TBTU / CH₂Cl₂ / 0.08 h

1.2: 89 percent / CH₂Cl₂ / 3 h

2.1: POCl₃ / CH₂Cl₂ / 1 h / 0 °C

2.2: LiAlH₄ / diethyl ether / 3 h / 0 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane;
DOI:10.1021/jm0495982