4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

Base Information

Chemical Name:4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester
CAS No.:220593-30-6
Molecular Formula:C₄₄H₅₄N₆O₉
Molecular Weight:810.948
Hs Code.:

4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-<i>tert</i>-butyl ester

Synonyms:4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

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Chemical Property of 4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

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Technology Process of 4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

There total 5 articles about 4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 194213-77-9
5-([2,2':6',2''-terpyridin]-4'-yloxy)pentan-1-amine

: 220593-29-3
4-(3-carboxy-5-nitro-benzoylamino)-4-methyl-heptanedioic acid di-tert-butyl ester

: 220593-30-6
4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 25 ℃; for 24h;
DOI:10.1039/a806509h

Reference yield:

: 220593-27-1
di-tert-butyl 4-nitro-4-methylheptanedicarboxylate

: 220593-30-6
4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / H₂ / Raney Ni / ethanol / 12 h / 25 °C / 3102.97 Torr

2.1: 58 percent / Et₃N / tetrahydrofuran / 12 h / -5 °C

3.1: DCC; 1-HOBt / dimethylformamide / 1 h / 25 °C

3.2: dimethylformamide

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; nickel; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja001401h

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 220593-30-6
4-methyl-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / NH₃ liq. / 12 h / -78 °C

2.1: 96 percent / H₂ / Raney Ni / ethanol / 12 h / 25 °C / 3102.97 Torr

3.1: 58 percent / Et₃N / tetrahydrofuran / 12 h / -5 °C

4.1: DCC; 1-HOBt / dimethylformamide / 1 h / 25 °C

4.2: dimethylformamide

With ammonia; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; nickel; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ja001401h