3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

Base Information

Chemical Name:3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride
CAS No.:1346862-74-5
Molecular Formula:C₁₈H₂₂Br₂N₂O₄*ClH
Molecular Weight:526.653
Hs Code.:

Synonyms:3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

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Chemical Property of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

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Technology Process of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

There total 6 articles about 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1346862-69-8
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminopropyl ester

: 1346862-74-5
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,3-dioxane; Inert atmosphere;
DOI:10.1021/ml200217u

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1346862-74-5
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / Heating; Inert atmosphere

1.2: Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / Heating; Inert atmosphere

3.1: alkali hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux

3.2: pH 2

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

4.2: 40 °C / Inert atmosphere

5.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / chloroform / Reflux; Inert atmosphere

6.1: hydrogenchloride / 1,3-dioxane / Inert atmosphere

With hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium tert-butylate; 1,1'-carbonyldiimidazole; trichlorophosphate; In 1,3-dioxane; ethanol; chloroform; water; N,N-dimethyl-formamide; 1.1: Vilsmeier formylation / 1.2: Vilsmeier formylation;
DOI:10.1021/ml200217u

Reference yield:

: 1346862-97-2
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminopropyl ester

: 1346862-74-5
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid N,N-dimethylaminoproyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / chloroform / Reflux; Inert atmosphere

2: hydrogenchloride / 1,3-dioxane / Inert atmosphere

With hydrogenchloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In 1,3-dioxane; chloroform;
DOI:10.1021/ml200217u