ethyl 3,3,5-trimethylcyclohexylcyanoacetate

Base Information

• Chemical Name: ethyl 3,3,5-trimethylcyclohexylcyanoacetate
• CAS No.: 114183-27-6
• Molecular Formula: C₁₄H₂₃NO₂
• Molecular Weight: 237.342
• Mol file: 114183-27-6.mol

Synonyms:ethyl 3,3,5-trimethylcyclohexylcyanoacetate

Chemical Property of ethyl 3,3,5-trimethylcyclohexylcyanoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3,3,5-trimethylcyclohexylcyanoacetate

There total 2 articles about ethyl 3,3,5-trimethylcyclohexylcyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 3,3,5-trimethylcyclohexylidenecyanoacetate (81831-40-5) → ethyl 3,3,5-trimethylcyclohexylcyanoacetate (114183-27-6)

Guidance literature:

With crosslinked polystirene anion exchange resin in BH₄- form; In ethanol; for 0.5h; Ambient temperature;

Reference yield:

cyano(4-methylcyclohexyl)acetic acid ethyl ester (57093-62-6) → ethyl 3,3,5-trimethylcyclohexylcyanoacetate (114183-27-6)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h;

DOI:10.1021/jo00136a004

Reference yield:

ethyl 3,3,5-trimethylcyclohexylcyanoacetate (114183-27-6) → 3,3,5-trimethylcyclohexane-1-acetic acid (3213-73-8)

Guidance literature:

With potassium hydroxide; In ethylene glycol;

DOI:10.1021/jo00136a004

upstream raw materials:

cyano(4-methylcyclohexyl)acetic acid ethyl ester

ethyl 3,3,5-trimethylcyclohexylidenecyanoacetate

Downstream raw materials:

3,3,5-trimethylcyclohexane-1-acetic acid

((1R,5S)-3,3,5-Trimethyl-cyclohexyl)-acetic acid methyl ester

((1R,5R)-3,3,5-Trimethyl-cyclohexyl)-acetic acid methyl ester

Refernces

• 1、 Nasipuri, Dhanonjoy,Sarkar, Ashis,Konar, Samir K.. "Stereochemistry of 1,4-Addition of Nucleophiles to Ethyl Cyclohexylidenecyanoacetates". . p. 2840 - 2845. Retrieved 2007/10/02.