(R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Base Information

Chemical Name:(R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one
CAS No.:197895-07-1
Molecular Formula:C₁₇H₁₄N₄O₃
Molecular Weight:322.323
Hs Code.:

Synonyms:(R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

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Chemical Property of (R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

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Technology Process of (R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

There total 4 articles about (R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 126252-50-4
(3R)-3-amino-5-phenyl-3,4,6,7-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one

: 197895-07-1
(R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Guidance literature:: (3R)-3-amino-5-phenyl-3,4,6,7-tetrahydropyrrolo<3,2,1-jk><1,4>benzodiazepin-4(3H)-one; With sulfuric acid; at 5 - 70 ℃;

With potassium nitrate; at 20 - 40 ℃; for 0.666667h;

Reference yield:

: 27158-79-8
1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

: 197895-07-1
(R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran; toluene / 30 h / -5 - 0 °C

1.2: 80 percent / isoamyl nitrite / tetrahydrofuran; toluene / 0.5 h / 0 °C

2.1: 94 percent / H₂ / 5percent Ru/C / methanol / 2 h / 80 °C / 6000.6 Torr

3.1: N-acetyl-L-phenylalanine / ethyl acetate / 0.08 h / Heating

3.2: 99 percent / 1 N NaOH / CH₂Cl₂ / 5 °C

4.1: 74 percent / KNO₃; H₂SO₄ / 0.67 h / 5 °C

With sulfuric acid; (S)-2-acetylamino-3-phenylpropanoic acid; potassium tert-butylate; hydrogen; potassium nitrate; 5percent Ru/C; In tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/jm000315p

Reference yield:

: 126167-36-0
1-phenyl-6,7-dihydro[1,4]diazepino[6,7,1-hi]indole-3,4-dione 3-oxime

: 197895-07-1
(R)-3-amino-9-nitro-1-phenyl-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / H₂ / 5percent Ru/C / methanol / 2 h / 80 °C / 6000.6 Torr

2.1: N-acetyl-L-phenylalanine / ethyl acetate / 0.08 h / Heating

2.2: 99 percent / 1 N NaOH / CH₂Cl₂ / 5 °C

3.1: 74 percent / KNO₃; H₂SO₄ / 0.67 h / 5 °C

With sulfuric acid; (S)-2-acetylamino-3-phenylpropanoic acid; hydrogen; potassium nitrate; 5percent Ru/C; In methanol; ethyl acetate;
DOI:10.1021/jm000315p