methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

Base Information

Chemical Name:methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate
CAS No.:274681-94-6
Molecular Formula:C₁₅H₂₂N₂O₄
Molecular Weight:294.351
Hs Code.:

Synonyms:methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

Suppliers and Price of methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

There total 14 articles about methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 274681-92-4
methyl (2S,3S)-2-azido-3-(tert-butoxycarbonylamino)-3-phenylpropionate

: 274681-94-6
methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1016/S0040-4020(01)00090-4

Reference yield: 42.0%

: 1572214-86-8
tert-butyl (S)-[(2S,5R)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazin-2-yl](phenyl)methylcarbamate

: 274681-94-6
methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

: methyl (2S,3S)-2,3-diamino-3-phenylpropanoate

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 20 ℃; for 54 - 72h; Overall yield = 60 %;
DOI:10.1016/j.tet.2014.01.040

Reference yield:

: 195624-97-6
(2R,3S)-3-acetylamino-2-hydroxy-3-phenylpropanoic acid isopropyl ester

: 274681-94-6
methyl (2S,3S)-2-amino-3-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / Et₃N / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 76 percent / DBU / CHCl₃ / 1 h / Heating

3: 90 percent / trimethylsilyl azide / methanol / 60 h / 70 - 80 °C

4: aq. HCl / dioxane / 12 h / 90 °C

5: HCl / 2.5 h / Heating

6: 129 mg / Et₃N / CH₂Cl₂ / 0 - 20 °C

7: 97 percent / H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With hydrogenchloride; trimethylsilylazide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; chloroform; ethyl acetate;
DOI:10.1016/S0040-4020(01)00090-4