5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

Base Information

Chemical Name:5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride
CAS No.:634605-47-3
Molecular Formula:C₂₅H₁₇ClN₄O₄*ClH
Molecular Weight:509.348
Hs Code.:

Synonyms:5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

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Chemical Property of 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

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Technology Process of 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

There total 7 articles about 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide

: 634605-47-3
5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; acetonitrile;

Reference yield:

: 754948-43-1
5-chloro-1H-indole

: 634605-47-3
5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / copper(II) oxide / DMF (N,N-dimethyl-formamide) / 16 h / Heating / reflux

2.1: methanol; hexane; dichloromethane / 20 °C

3.1: dichloromethane / 0 - 30 °C

3.2: -65 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / DMF (N,N-dimethyl-formamide); dichloromethane / 0.5 h / 20 °C

5.2: 20 °C

6.1: hydrogenchloride / methanol; acetonitrile

With hydrogenchloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; copper(II) oxide; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; acetonitrile;

Reference yield:

: 29681-44-5
5-bromo-3-pyridine carboxylic acid methyl ester

: 634605-47-3
5-{5-chloro-3-[4-(2-methoxyphenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-indol-1-yl}-nicotinamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / copper(II) oxide / DMF (N,N-dimethyl-formamide) / 16 h / Heating / reflux

2.1: methanol; hexane; dichloromethane / 20 °C

3.1: dichloromethane / 0 - 30 °C

3.2: -65 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / DMF (N,N-dimethyl-formamide); dichloromethane / 0.5 h / 20 °C

5.2: 20 °C

6.1: hydrogenchloride / methanol; acetonitrile

With hydrogenchloride; potassium tert-butylate; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; copper(II) oxide; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); hexane; dichloromethane; acetonitrile;