C₃₅H₃₃N₇O

Base Information

• Chemical Name: C₃₅H₃₃N₇O
• CAS No.: 1369594-59-1
• Molecular Formula: C₃₅H₃₃N₇O
• Molecular Weight: 567.693
• Mol file: 1369594-59-1.mol

Synonyms:C₃₅H₃₃N₇O

Chemical Property of C₃₅H₃₃N₇O

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₃₃N₇O

There total 6 articles about C₃₅H₃₃N₇O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-bromo-2'-hydroxyacetophenone (30186-18-6) → C35H33N7O (1369594-59-1)

Guidance literature:

Multi-step reaction with 6 steps

1: acetic acid / ethanol / 6 h / Reflux

2: PPA / 2 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

5: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 15 h / Inert atmosphere; Reflux

6: hydrogenchloride / methanol / 3 h / 20 °C

With hydrogenchloride; potassium acetate; sodium carbonate; potassium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

C45H49N7O5 (1369594-58-0) → C35H33N7O (1369594-59-1)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 3h;

Reference yield:

C14H12Br2N2O (1369594-43-3) → C35H33N7O (1369594-59-1)

Guidance literature:

Multi-step reaction with 5 steps

1: PPA / 2 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

4: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 15 h / Inert atmosphere; Reflux

5: hydrogenchloride / methanol / 3 h / 20 °C

With hydrogenchloride; potassium acetate; sodium carbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

4'-bromo-2'-hydroxyacetophenone

C₁₄H₁₂Br₂N₂O

5-bromo-2-(5-bromo-1H-indol-2-yl)phenol

3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole

Downstream raw materials:

N,N'-[[(6S)-6-phenyl-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl-[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis[carbamic acid] C,C'-dimethyl ester

C₄₉H₅₅N₉O₇