Technology Process of (2Z,13E)-1-benzyloxy-3,8,8,14,18-pentamethyl-11-methylene-2,13,17-nonadecatrien-7-ol
There total 20 articles about (2Z,13E)-1-benzyloxy-3,8,8,14,18-pentamethyl-11-methylene-2,13,17-nonadecatrien-7-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 94 percent / LiAlH4 / tetrahydrofuran / 1) 4.5h reflux 2) 2h at r.t.
3: 97 percent / pyridine / 16 h / Ambient temperature
4: 56 percent / Li / liquid ammonia; diethyl ether / 0.42 h / -33 °C
5: 90 percent / CrO3/pyridine complex / CH2Cl2 / 1.5 h / Ambient temperature
6: 1) Mg / Br(CH2)2Br / 1) ether/1h/reflux 2) 1h reflux,then 18.5h at r.t.
With
pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; lithium; magnesium; ethylene dibromide;
In
tetrahydrofuran; pyridine; diethyl ether; dichloromethane; ammonia;
DOI:10.1021/jo01301a028
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / PBr3 / hexane / 0.33 h / 0 °C
3: 94 percent / LiAlH4 / tetrahydrofuran / 1) 4.5h reflux 2) 2h at r.t.
4: 97 percent / pyridine / 16 h / Ambient temperature
5: 56 percent / Li / liquid ammonia; diethyl ether / 0.42 h / -33 °C
6: 90 percent / CrO3/pyridine complex / CH2Cl2 / 1.5 h / Ambient temperature
7: 1) Mg / Br(CH2)2Br / 1) ether/1h/reflux 2) 1h reflux,then 18.5h at r.t.
With
pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; phosphorus tribromide; lithium; magnesium; ethylene dibromide;
In
tetrahydrofuran; pyridine; diethyl ether; hexane; dichloromethane; ammonia;
DOI:10.1021/jo01301a028
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaH / DME 1) 80-85 deg C/ 1.5 h 2a) 1h reflux 2b) 16 h at r.t.
2: 1) O3 / pyridine 2) Me2S / 1) CH2Cl2 / -78 deg C 2) r.t./overnight
3: 87 percent / NaBH4 / ethanol / 3.5 h / Ambient temperature
4: 93 percent / pyridine / 24 h / 0 °C
5: 92 percent / LiBr / acetone / 21.5 h / Heating
6: 1) Mg / Br(CH2)2Br / 1) ether/1h/reflux 2) 1h reflux,then 18.5h at r.t.
With
pyridine; sodium tetrahydroborate; dimethylsulfide; sodium hydride; ozone; magnesium; ethylene dibromide; lithium bromide;
In
pyridine; ethanol; acetone;
DOI:10.1021/jo01301a028
