4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

Base Information

Chemical Name:4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide
CAS No.:1557244-86-6
Molecular Formula:C₁₂H₁₇NO₃S
Molecular Weight:255.338
Hs Code.:

Synonyms:4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

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Chemical Property of 4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

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Technology Process of 4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

There total 5 articles about 4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1557244-86-6
4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 2.83h;

Reference yield:

: ethyl (1R,3R)-2,2-dimethyl-3-(4-sulfamoylphenyl)cyclopropanecarboxylate

: 1557244-86-6
4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

Reference yield:

: trans-2,2-dimethyl-3-phenylcyclopropanecarboxylic acid

: 1557244-86-6
4-[(1R,3R)-3-(hydroxymethyl)-2,2-dimethylcyclopropyl]benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Lux-5u / methanol / Resolution of racemate

2.1: thionyl chloride / 1 h / 0 - 20 °C

3.1: chlorosulfonic acid / chloroform / 2.5 h / 0 - 20 °C

3.2: 0.5 h / 5 - 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / 0 °C

With chlorosulfonic acid; thionyl chloride; diisobutylaluminium hydride; In tetrahydrofuran; methanol; hexane; chloroform;