Technology Process of 2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-5-pentanoic acid
There total 10 articles about 2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-5-pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-tert-butoxycarbonylamino-5-(4'-dibenzofuran-4-yl-biphen-4-yl)-5-pentanoic acid methyl ester;
With
methanol; potassium hydroxide; water;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol; water;
pH=2;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 1034.32 Torr / Parr apperatous
2: potassium hydroxide; water / tetrahydrofuran; methanol / 1 h / 0 - 20 °C
With
potassium hydroxide; water; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane / 3 h / -78 - 20 °C
1.2: 2.5 h / -78 - 20 °C
2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 2 h / Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h / 1034.32 Torr / Parr apperatous
4.1: potassium hydroxide; water / tetrahydrofuran; methanol / 1 h / 0 - 20 °C
With
potassium hydroxide; water; hydrogen; boron tribromide; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;
2.1: Suzuki Coupling;
