Cycl[2.2.3]azine

Base Information

• Chemical Name: Cycl[2.2.3]azine
• CAS No.: 209-81-4
• Molecular Formula: C10H7N
• Molecular Weight: 141.17
• Mol file: 209-81-4.mol

Synonyms:

Chemical Property of Cycl[2.2.3]azine

Chemical Property:

• Melting Point: 64-65 °C (sublm)
• PSA: 4.41000
• Density: 1.19g/cm³
• LogP: 2.53030

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cycl[2.2.3]azine

There total 19 articles about Cycl[2.2.3]azine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

Pyrrolo[2,1,5-cd]indolizine-5,6-dicarboxylic acid (71268-02-5) → pyrrolo[2,1,5-cd]indolizine (209-81-4)

Guidance literature:

copper chromite; In quinoline; at 230 ℃; for 5h;

DOI:10.1039/P19800001319

Reference yield: 46.0%

3H-pyrrolizine (251-60-5) + 1-dimethylamino-3-dimethylimonioprop-1-ene perchlorate → pyrrolo[2,1,5-cd]indolizine (209-81-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 45h; Heating;

Reference yield: 30.0%

pyrrolo[2,1,5-cd]indolizine-1,2-dicarboxylic acid (94891-76-6) → pyrrolo[2,1,5-cd]indolizine (209-81-4)

Guidance literature:

With CuCrO₄; copper; In quinoline; for 5h; Heating;

upstream raw materials:

5-methyl-indolizine

pyrrolo[2,1,5-cd]indolizine-1,2-dicarboxylic acid

3H-pyrrolizine

1,3-bis-dimethylaminotrimethinium perchlorate

Downstream raw materials:

1,4-Dibrom-cycl(3.2.2)azin

Refernces

• 1、 Galbraith et al.. "-". . p. 582. Retrieved 1959.
• 2、 Laws, Andrew P.,Taylor, Roger. "The Quantitative Electrophilic Reactivity of Annulenes. Part 2. Partial Rate Factors for Hydrogen Exchange of Azulene, Cyclazine, Indolizine, N-Methylisoindole, Indole, and Pyrrolothiazole, and Attempted Exchange in trans-9,10-Dimethyldihydropyrene: the Dramatic Effect o...". . p. 591 - 598. Retrieved 2007/10/02.
• 3、 Jessep, Michael A.,Leaver, Derek. "Heterocyclic Compounds with Bridgehead Nitrogen Atoms. Part 7. The Synthesis of Pyrroloindolizines (Cyclazines) and Pyrazinopyrrolizines (6-Azacyclazines) from 3H-Pyrrolizine". . p. 1319 - 1323. Retrieved 2007/10/02.