(S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Base Information

Chemical Name:(S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate
CAS No.:916219-97-1
Molecular Formula:C₁₃H₁₅N₃O₃
Molecular Weight:261.28
Hs Code.:

Synonyms:(S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Suppliers and Price of (S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

There total 4 articles about (S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865233-37-0
(3S)-3-[4-(4'-trifluoromethyl-biphenyl-3-ylmethoxy)-phenyl]-hex-4-ynoic acid methyl ester

: 916219-97-1
(S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen; quinoline / ethyl acetate / 8 h / Inert atmosphere

2.1: 2,6-dimethylpyridine; osmium(VIII) oxide / water; tert-butyl alcohol / 0.08 h

2.2: 20 - 30 °C

3.1: potassium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / water; acetonitrile / 3 h / -5 - 0 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonia / dichloromethane; propan-1-ol / 8 h / Inert atmosphere

5.1: 0.5 h / 80 °C / Inert atmosphere

5.2: 0.75 h / 35 - 80 °C / Inert atmosphere

6.1: hydrogen; 5%-palladium/activated carbon / water; ethyl acetate / 8 h

With 2,6-dimethylpyridine; quinoline; sodium chlorite; potassium dihydrogenphosphate; osmium(VIII) oxide; 5%-palladium/activated carbon; ammonia; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In propan-1-ol; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ml400501x

Reference yield:

: C₂₇H₂₅F₃O₃

: 916219-97-1
(S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine; osmium(VIII) oxide / water; tert-butyl alcohol / 0.08 h

1.2: 20 - 30 °C

2.1: potassium dihydrogenphosphate; dihydrogen peroxide; sodium chlorite / water; acetonitrile / 3 h / -5 - 0 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonia / dichloromethane; propan-1-ol / 8 h / Inert atmosphere

4.1: 0.5 h / 80 °C / Inert atmosphere

4.2: 0.75 h / 35 - 80 °C / Inert atmosphere

5.1: hydrogen; 5%-palladium/activated carbon / water; ethyl acetate / 8 h

With 2,6-dimethylpyridine; sodium chlorite; potassium dihydrogenphosphate; osmium(VIII) oxide; 5%-palladium/activated carbon; ammonia; hydrogen; dihydrogen peroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In propan-1-ol; dichloromethane; water; ethyl acetate; acetonitrile; tert-butyl alcohol;
DOI:10.1021/ml400501x

Reference yield:

: 916219-96-0
C₂₅H₂₂F₃NO₄

: 916219-97-1
(S)-methyl 3-(4-hydroxyphenyl)-3-(2-methyl-2H-1,2,4-triazol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.5 h / 80 °C / Inert atmosphere

1.2: 0.75 h / 35 - 80 °C / Inert atmosphere

2.1: hydrogen; 5%-palladium/activated carbon / water; ethyl acetate / 8 h

With 5%-palladium/activated carbon; hydrogen; In water; ethyl acetate;
DOI:10.1021/ml400501x