3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine

Base Information

Chemical Name:3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine
CAS No.:867287-55-6
Molecular Formula:C₄₀H₃₂F₂N₆O₉
Molecular Weight:778.726
Hs Code.:

Synonyms:3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine

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Chemical Property of 3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine

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Technology Process of 3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine

There total 2 articles about 3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 867287-47-6
3,5-di-O-benzoyl-2-C-β-difluoromethyl-α-D-ribofuranosyl bromide

: 112233-74-6
N²-acetyl-O⁶-(diphenylcarbamoyl)guanine

: 867287-55-6
3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine

Guidance literature:: N²-acetyl-O⁶-(diphenylcarbamoyl)guanine; With bis-(trimethylsilyl)acetamide; In 1,2-dichloro-ethane; at 80 ℃; for 0.25h;

3,5-di-O-benzoyl-2-C-β-difluoromethyl-α-D-ribofuranosyl bromide; With mercury dibromide; mercury(II) oxide; In toluene; at 80 ℃; for 2h;
DOI:10.1021/jo0507542

Reference yield:

: 1,2,3,5-tetra-O-benzoyl-2-C-β-difluoromethyl-D-ribofuranose

: 867287-55-6
3',5'-di-O-benzoyl-2-N-acetyl-6-O-diphenylcarbamoyl-2'-C-β-difluoromethylguanosine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / HBr; AcOH / 5 h / 80 °C

2.1: bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 0.25 h / 80 °C

2.2: 31 percent / HgO; HgBr₂ / toluene / 2 h / 80 °C

With hydrogen bromide; acetic acid; bis-(trimethylsilyl)acetamide; In 1,2-dichloro-ethane;
DOI:10.1021/jo0507542